2023 Multiple Myeloma Updates: from bench to bedside

Eventi 2023

2023 Multiple Myeloma Updates: from bench to bedside

Dates: 20-21 Novembre 2023

Location: Genova, Italy

Dear Colleagues and Friends,
the President of the Congress, together with the Scientific Committee, will join for an unforgettable meeting in Genoa, Italy.

Over the recent years significant progress has been achieved in Multiple Myeloma biology resulting in novel therapeutic strategies as well as changes in the whole treatment paradigm.

Thus, the time has come for a thorough biological and clinical update. This international meeting aims to deliver state of the art focused on the latest biological and clinical advances in Multiple Myeloma and on improving patient care. A number of internationally recognized speakers, coming from our own and other countries, are expected to deliver updates lectures on cutting edge topics. These will include genetic and epigenetic features of biology, molecular and biological mechanisms of disease progression, new prognostic factors and novel approaches to evaluate the response to therapy, new therapeutic molecules and combinations targeting tumor cells and/or their microenvironment. Novel immunotherapy strategies will also be the object of intensive scrutiny.

We are confident that at the end of the meeting all of us will be enriched with fresh stimuli and renewed enthusiasm, with the deep awareness that the enduring challenges posed by Multiple Myeloma may now be faced with more rational and effective achievements.

See you in Genoa !

Prof. Roberto Massimo Lemoli
Congress President

Additional information

Date

November 20/21, 2023

Venue

NH Genova Marina Hotel
Molo Ponte Calvi, 5
16124 Genova -Italia

- The NH Genova Marina hotel is part of Genoa’s Old Port area,developed by world-famous architect Renzo Piano. It sits on specially-designed ‘stilts’, steps from the impressive Aquarium and Sea Museum. It’s also the closest hotel to this amazing attraction: ‘Ponte dei Mille’ cruise terminal, aquarium, science museum, Great Nautical museum, and the Galeone Neptune (Neptune Galleon). It’s only a 10-minute walk from the Genoa’s historic city center.

How to reach the Venue

From the airport

From the Genoa Airport – Cristoforo Colombo
Taxi: It’s a 25 minutes trip and costs around €20.
Aerobus shuttle: Departs every 40 minutes and costs €6.00. Take the Volabus bus that links the city center and Genoa Airport. Get off at Genova Piazza Principe. The hotel is a kilometer away.

From the train station

From Darsena metro stop: The hotel is 230 meters away.
Closest metro station: Darsena metro
Ticket (100 min): 1.50€ Ticket (24h): 4.50€

By car

The hotel’s GPS Coordinates:44.4110317°N 8.926434500000028°E
Parking: Onsite. €1.80 / hour. €20.00 / day. Parking cannot be reserved in advance. Click here to get directions.

Congress President

Prof. LEMOLI Roberto Massimo
Scuola di Medicina e Scienze Farmaceutiche, Università di Genova
Dipartimento di Medicina Interna e Specialità Mediche (DIMI)
Direttore Clinica Ematologica, IRCCS Policlinico San Martino – IST, Genova
Genova

Scientific Committee

M. Cea (Chair)
A. Cagnetta
M. Garibotto
M. Olivieri
E. Catini
M. Gallo
A. Laserra

Anderson	Kenneth Carl	Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School	Boston	USA
Angelucci	Emanuele	Policlinico San Martino	Genova	Italy
Boccadoro	Mario	University of Turin	Torino	Italy
Bolli	Niccolò	Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico	Milano	Italy
Bringhen	Sara	University of Turin	Torino	Italy
Bruno	Benedetto	University of Turin	Torino	Italy
Cagnetta	Antonia	University of Genova	Genova	Italy
Cavo	Michele	University of Bologna	Bologna	Italy
Cea	Michele	University of Genoa	Genova	Italy
D’Agostino	Mattia	University of Turin	Torino	Italy
Di Raimondo	Francesco	University of Catania	Catania	Italy
Fulciniti	Mariateresa	Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School	Boston	USA
Giuliani	Nicola	University of Parma	Parma	Italy
Gobbi	Marco	University of Genoa	Genova	Italy
Larocca	Alessandra	University of Turin	Torino	Italy
Lemoli	Roberto Massimo	University of Genoa	Genova	Italy
Mangiacavalli	Silvia	University of Pavia	Pavia	Italy
Massaia	Massimo	University of Turin	Torino	Italy
Mina	Roberto	University of Turin	Torino	Italy
Munshi	Nikhil	Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School	Boston	USA
Neri	Antonino	USL-IRCCS di Reggio Emilia	Reggio Emilia	Italy
Oliva	Stefania	University of Turin	Torino	Italy
Palladini	Giovanni	University of Pavia	Pavia	Italy
Ria	Roberto	University of Bari	Bari	Italy
Roccaro	Aldo	ASST Spedali Civili	Brescia	Italy
Rodríguez-Otero	Paula	Clinica Universidad de Navarra	Pamplona	Spain
Ruggeri	Piero	Dean of the School of Medical and Pharmaceutical Sciences, University of Genoa	Genova	Italy
Tacchetti	Paola	University of Bologna	Bologna	Italy
Terragna	Carolina	University of Bologna	Bologna	Italy
Uccelli	Antonio	Scientific Director iRCCS Policlinico San Martino	Genova	Italy
Zamagni	Elena	University of Bologna	Bologna	Italy

Monday – November 20^th, 2023

08:30 Registration

OPENING SESSION

09:00 Welcome address R.M. Lemoli, P. Ruggeri, A. Uccelli

09:30 Lecture: Cellular Therapy for Multiple Myeloma: What’s Now and What’s Next N.C. Munshi

Introducing M. Cea

GENETICS AND EPIGENETICS OF MULTIPLE MYELOMA

Chairs: M. Cea, N. Giuliani

10:20 Functional impact of genomic complexity of the transcriptome of Multiple Myeloma N. Bolli

10:45 miRNA and lncRNA of bone marrow microenvironment as support for Myeloma plasma cells A. Neri

11:10 Epigenetic architecture in Multiple Myeloma A. Roccaro

11:35 Drugging Transcription factors in Multiple Myeloma M.T. Fulciniti

12:00 Current Risk Stratification M. D’Agostino

12:25 Clonal Hematopoiesis as a biomarker in Multiple Myeloma C. Terragna

12:50 Lunch

14:00 Lecture: Changing landscape in the diagnosis and treatment of Multiple Myeloma K.C. Anderson

Introducing R.M. Lemoli

BIOLOGY OF DISEASE PROGRESSION AND ORGAN DAMAGE IN MULTIPLE MYELOMA

Chairs: M. Boccadoro, A. Neri

14:50 Circulating tumor cells and homing to predict Myeloma progression R. Ria

15:15 Molecular pathways governing the pathogenesis of Myeloma bone disease N. Giuliani

15:40 Emerging therapeutic targets in Multiple Myeloma M. Cea

16:05 Coffee break

16:20 Novel strategies for the management of AL Amyloidosis G. Palladini

16:45 Management of Monoclonal Gammopathy of Clinical Significance A. Cagnetta

17:10 The Consultant’s Guide to Smouldering Multiple Myeloma E. Zamagni

17:35 Closing – M. Cea, R. M. Lemoli

Tuesday – November 21^st , 2023

MULTIPLE MYELOMA CLINICAL UPDATES

Chairs: M. Cavo, M. Gobbi

09:00 Frontline therapy for newly diagnosed young patients R. Mina

09:25 Newly diagnosed elderly and very elderly Myeloma patients S. Bringhen

09:50 Optimal Therapy for High Risk Myeloma (newly diagnosed and relapsed) P. Tacchetti

10:15 Coffee break

CLINICAL MANAGEMENT OF MULTIPLE MYELOMA PATIENTS

Chairs: M. Cavo, M. Gobbi

10:30 Clinical or biochemical progression of Myeloma: when patients need treatment F. Di Raimondo

10:55 Lenalidomide-based triplet regimens in first relapsed Multiple Myeloma patients: real-world evidence S. Mangiacavalli

11:20 The choice of therapy at first relapse: focus on Len-refractoryP atients A. Larocca

11:45 Disease monitoring: how to use MRD in clincal practice S. Oliva

HARNESSING IMMUNITY FOR MM TREATMENT

Chairs: E. Angelucci, R.M. Lemoli

12:10 Understanding mechanisms of resistance to immunotherapies Integrating cellular therapy in the treatment P. Rodriguez Otero

12:35 Optimizing Monoclonal AntIbodies therapy for Multiple Myeloma: new targets and new agents M. Cavo

13.00 The immunosuppressive microenvironment of Multiple Myeloma M. Massaia

13:25 CAR T cells and bispecific antibodies in MM: how to tailor immunotherapy? B. Bruno

13:50 Closing Remarks – M. Cea, R. M. Lemoli

14:00 CME Test

Closing of the congress

SCARICA LA LOCANDINA: Locandina Multiple Myeloma 2023

Monday – November 20^th, 2023

Cliccare sul titolo della relazione per scaricare le slides in formato .pdf

OPENING SESSION

09.30 Lecture: Cellular Therapy for Multiple Myeloma: What’s Now and What’s Next N.C. Munshi – Pubblicazione non autorizzata

GENETICS AND EPIGENETICS OF MULTIPLE MYELOMA

Chairs: M. Cea, N. Giuliani

10.20 Functional impact of genomic complexity of the transcriptome of Multiple Myeloma N. Bolli – Pubblicazione non autorizzata

10.45 miRNA and lncRNA of bone marrow microenvironment as support for Myeloma plasma cells – A. Neri

11.10 Epigenetic architecture in Multiple Myeloma A. Roccaro – Pubblicazione non autorizzata

11.35 Drugging Transcription factors in Multiple Myeloma M.T. Fulciniti – Pubblicazione non autorizzata

12.00 Current Risk Stratification – M. D’Agostino

12.25 Clonal Hematopoiesis as a biomarker in Multiple Myeloma – C. Terragna

14.00 Lecture: Changing landscape in the diagnosis and treatment of Multiple Myeloma K.C. Anderson

– Pubblicazione non autorizzata

BIOLOGY OF DISEASE PROGRESSION AND ORGAN DAMAGE IN MULTIPLE MYELOMA

Chairs: M. Boccadoro, A. Neri

14.50 Circulating tumor cells and homing to predict Myeloma progression – R. Ria

15.15 Molecular pathways governing the pathogenesis of Myeloma bone disease N. Giuliani – Pubblicazione non autorizzata

15.40 Emerging therapeutic targets in Multiple Myeloma – M. Cea

16.20 Novel strategies for the management of AL Amyloidosis – (G. Palladini) – P. Milani

16.45 Management of Monoclonal Gammopathy of Clinical Significance – A. Cagnetta

17.10 The Consultant’s Guide to Smouldering Multiple Myeloma – E. Zamagni

Tuesday – November 21^st , 2023

Cliccare sul titolo della relazione per scaricare le slides in formato .pdf

MULTIPLE MYELOMA CLINICAL UPDATES

Chairs: M. Cavo, M. Gobbi

09.00 Frontline therapy for newly diagnosed young patients (R. Mina) – G. Bertuglia

09.25 Newly diagnosed elderly and very elderly Myeloma patients – S. Bringhen

09.50 Optimal Therapy for High Risk Myeloma (newly diagnosed and relapsed) – P. Tacchetti

CLINICAL MANAGEMENT OF MULTIPLE MYELOMA PATIENTS

Chairs: M. Cavo, M. Gobbi

10.30 Clinical or biochemical progression of Myeloma: when patients need treatment – F. Di Raimondo

10.55 Lenalidomide-based triplet regimens in first relapsed Multiple Myeloma patients: real-world evidence – S. Mangiacavalli

11.20 The choice of therapy at first relapse: focus on Len-refractory Patients – A. Larocca – Pubblicazione non autorizzata

11.45 Disease monitoring: how to use MRD in clinical practice – S. Oliva

HARNESSING IMMUNITY FOR MM TREATMENT

Chairs: E. Angelucci, R.M. Lemoli

12.10 Understanding mechanisms of resistance to immunotherapies Integrating cellular therapy in the treatment – P. Rodriguez Otero – Pubblicazione non autorizzata

12:35 Optimizing Monoclonal AntIbodies therapy for Multiple Myeloma: new targets and new agents – M. Cavo – Pubblicazione non autorizzata

13.00 The immunosuppressive microenvironment of Multiple Myeloma – M. Massaia – Pubblicazione non autorizzata

13.25 CAR T cells and bispecific antibodies in MM: how to tailor immunotherapy? – B. Bruno

CME Credits Continuing Medical Education (Valid for Italian CME only)

Event:

Residential

ID Event:

1038- 389794

N° of credits:

n. 8,4 CME Italian Credits

Professions:

Medical Doctors (All disciplines)
Biologists

To earn CME credits from the event, you must:

Participate in at least 90% of the learning activities
Give correct answers to at least 75% of the questions on the CME questionnaire. The test will be available at the end of the meeting.
Fill out the perceived-quality form & survey • Sign the “sign-in sheet” at the start and end of the Congress

Provider:

Staff P&P – Provider ECM N° 1038

Congress registration is FREE.

Pre-registration online is mandatory due to limited seat availability.

Registrants will be admitted based on the “first come-first served” rule (date of registration will be considered), until the maximum number allowed is reached. This event will be only in-presence

The attendance is guaranteed only to pre-registered participants.

Pre-registrations should be submitted online before November 5th, 2023